|
KMID : 0043320010240010039
|
|
Archives of Pharmacal Research
2001 Volume.24 No. 1 p.39 ~ p.43
|
|
|
Photocleavage of DNA by 4’-Bromoacetophenone Analogs
|
|
Jeon R
Wender P
|
|
|
Abstract
|
|
|
|
4’-Bromoacetophenone analogs, which are able to generate monophenyl radicals capable of hydrogen atom abstraction, were investigated as possible photoinducible DNA cleaving agents. The potential of 4’- bromoacetophenone as a possible new DNA cleaver is explored. Pyrrolecarboxatmid conjugated 4’-bromoacetophenones, in particular, DNA cleaving activity and sequence-selectivity on the contiguous AT base pair sites.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|